标題: Incorporation of Layered Rectorite into Biocompatible Core-Sheath Nanofibrous Mats for Sustained Drug Delivery

作者: Tu, H (Tu, Hu); Dai, FF (Dai, Fangfang); Cheng, G (Cheng, Gu); Yuan, MQ (Yuan, Mengqin); Zhou, X (Zhou, Xue); Wang, YQ (Wang, Yanqing); Zhang, RQ (Zhang, Ruquan); Zheng, YJ (Zheng, Yajing); Cheng, YX (Cheng, Yanxiang); Deng, HB (Deng, Hongbing)

來源出版物: ACS BIOMATERIALS SCIENCE & ENGINEERING  卷:7 期:9 頁: 4509-4520 DOI: 10.1021/acsbiomaterials.1c00638 出版年: SEP 13 2021  

摘要: Searching for drug carries with controlled release and good biocompatibility has always been one of the research hotspots and difficulties. Herein, core-sheath nanofibrous mats (NFs) consisting of biocompatible poly(ethylene oxide) (PEO, core) and poly(L-lactic acid) (PLLA, sheath) for drug delivery were fabricated via coaxial electrospinning strategy. The nontoxic layered silicate rectorite (REC) with 0.5-1 wt % amount was introduced in the sheath for sustained drug delivery. Layered REC could be intercalated with PLLA macromolecule chains, leading to the densified structure for loading and keeping doxorubicin hydrochloride (DOX) while reversibly capturing and releasing DOX to delay the drug migration due to its high cation activity. The addition of REC in NFs could delay the initial burst release of DOX and prolong the residence time from 12 to 96 h. Moreover, DOX-loaded core-sheath NFs had in vitro culture with strong antitumor activity, which was confirmed by cytotoxicity results and live and dead assay. HepG(2) tumor-bearing xenograft further demonstrated the tumor-suppression effect and the excellent safety of the DOX-loaded core-sheath NFs in vivo. The constructed NFs as drug carriers showed great potential in the local treatment of solid tumors.

作者關鍵詞: controlled release; rectorite; coaxial electrospinning; antitumor effects; drug delivery

地址: [Tu, Hu; Deng, Hongbing] Wuhan Univ, Sch Resource & Environm Sci, Hubei Engn Ctr Nat Polymers Based Med Mat,Hubei K, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Peoples R China.

[Tu, Hu; Zhang, Ruquan] Wuhan Text Univ, State Key Lab New Text Mat & Adv Proc Technol, Wuhan 430200, Peoples R China.

[Dai, Fangfang; Yuan, Mengqin; Wang, Yanqing; Zheng, Yajing; Cheng, Yanxiang] Wuhan Univ, Dept Obstet & Gynecol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.

[Cheng, Gu] Wuhan Univ, Stomatol Hosp, Dept Oral & Maxillof Trauma & Plast Surg, Hubei MOST KLOS & KLOBME, Wuhan 430079, Peoples R China.

[Zhou, Xue] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Peoples R China.

通訊作者地址: Deng, HB (通訊作者)，Wuhan Univ, Sch Resource & Environm Sci, Hubei Engn Ctr Nat Polymers Based Med Mat,Hubei K, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Peoples R China.

電子郵件地址: hbdeng@whu.edu.cn

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