标題: Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

作者: Cao, SY (Cao, Shiyi); Wu, SQ (Wu, Shuangquan); Dong, XY (Dong, Xiangyang); Long, M (Long, Min); Lin, H (Lin, Heng); Liu, FT (Liu, Fangtian); Wu, Y (Wu, Yang); Zhao, Z (Zhao, Ze); Chen, CJ (Chen, Chaoji); Deng, HB (Deng, Hongbing)

來源出版物: ADVANCED FUNCTIONAL MATERIALS DOI: 10.1002/adfm.202215059 提前訪問日期: FEB 2023

摘要: Emerging adsorption technology shows great potential for Pb2+ removal in the human body because of its high adsorption efficiency and easy operation. However, biosafety concerns in the human body limit the development of adsorbents in integrated lead removal for acute poisoning in humans from the gastrointestinal tract and even the blood. In this work, highly bio-safe and natural saccharomyces cerevisiae cells are immobilized on the interworking natural regenerated cellulose nanofibers network for integrated lead removal in the human body. High intrinsic biosafety of the aerogel is guaranteed due to the biocompatibility of aerogel composition and the absence of cross-linking substances. Attributing to the porous structure of cellulose nanofibrous scaffolds, saccharomyces cerevisiae cells are protected from shedding, and considerable loading sites for saccharomyces cerevisiae cells are ensured. Simultaneously, abundant functional groups on the saccharomyces cerevisiae cells exhibit superior adsorption ability with a saturated adsorption capacity of lead ions as high as 107 mg g(-1) in the aquatic environment. After adsorption, Pb2+ concentration decreases from 879.70 to 248.53 mu g L-1 in the intestinal phase and from 400 to 186.29 mu g L-1 (within a safe level) in blood, providing an attractive strategy for detoxification of integrated lead in the human body.

作者關鍵詞: aerogels; biomass wastes; biosafety; gastrointestinal tracts; lead poisoning; lead removal

地址: [Cao, Shiyi; Dong, Xiangyang; Long, Min; Lin, Heng; Liu, Fangtian; Wu, Yang; Zhao, Ze; Chen, Chaoji; Deng, Hongbing] Wuhan Univ, Hubei Engn Ctr Nat Polymers based Med Mat, Hubei Key Lab Biomass Resource Chem & Environm Bio, Sch Resource & Environm Sci,Hubei Int Sci & Techno, Wuhan 430079, Peoples R China.

[Wu, Shuangquan] Wuhan Univ, Inst Hepatobiliary Dis, Natl Qual Control Ctr Donated Organ Procurement, Transplant Ctr,Zhongnan Hosp,Natl Qual Control Ctr, Wuhan 430079, Peoples R China.

[Lin, Heng] Wuhan Univ, Hubei Key Lab Auton Nervous Syst Modulat, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.

通訊作者地址: Chen, CJ; Deng, HB (通訊作者)，Wuhan Univ, Hubei Engn Ctr Nat Polymers based Med Mat, Hubei Key Lab Biomass Resource Chem & Environm Bio, Sch Resource & Environm Sci,Hubei Int Sci & Techno, Wuhan 430079, Peoples R China.

電子郵件地址: chenchaojili@whu.edu.cn; hbdeng@whu.edu.cn

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