标題：Remote controlled drug release from multi-functional Fe3O4/GO/Chitosan microspheres fabricated by an electrospray method作者：Li, S (Li, Sheng); Xiao, L (Xiao, Ling); Deng, HB (Deng, Hongbing); Shi, XW (Shi, Xiaowen); Cao, QH (Cao, Qihua)

來源出版物：COLLOIDS AND SURFACES B-BIOINTERFACES 卷：151 頁碼：354-362 DOI：10.1016/j.colsurfb.2016.12.029出版年：

摘要：The construction of multifunctional microspheres for remote controlled drug release requires the exquisite selection of composite materials and preparation approaches. In this study, chitosan, an amino polysaccharide, was blended with inorganic nanocomponents, Fe3O4 and graphene oxide (GO) and electrosprayed to fabricate uniform microspheres with the diameters ranging from 100 mu m to 1100 mu m. An anti-cancer drug, doxorubicin (DOX), was loaded to the microspheres by an adsorption or embedding method. The microsphere is responsive to magnetic fields due to the presence of Fe3O4, and the incorporation of GO enhanced the drug loading capacity. The fast stimuli-responsive release of DOX can be facilely controlled by using NIR irradiation due to the strong photo-thermal conversion of Fe3O4 and GO, In addition, ultrasound was used as another external stimulus for DOX release. The results suggest the Fe3O4/GO/Chitosan microspheres fabricated by the electrospray method provide an efficient platform for remote controlled drug release, which may have potential applications in drug eluting microspheres.

入藏号：WOS:000394475400042

文獻類型：Article

語種：English

作者關鍵詞：Chitosan microsphere; Electrospray; Remote controlled release; NIR; Ultrasound

擴展關鍵詞：IN-VIVO EVALUATION; GRAPHENE OXIDE; HEPATOCELLULAR-CARCINOMA; CHITOSAN MICROSPHERES; ELUTING MICROSPHERES; PHOTOTHERMAL THERAPY; TRANSARTERIAL CHEMOEMBOLIZATION; CANCER-CELLS; DELIVERY; NANOPARTICLES

通訊作者地址： Xiao, L (reprint author), Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430072, Hubei Province, Peoples R China.。

電子郵件地址：lfrcs@163.com; xiaoling9119@whu.edu.cn; hbdeng@whu.edu.cn; shixwwhu@163.com; caoqh@whu.edu.cn

地址： [Li, Sheng; Xiao, Ling; Deng, Hongbing; Shi, Xiaowen; Cao, Qihua] Wuhan Univ, Sch Resource & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430072, Peoples R China.

研究方向：Biophysics; Chemistry; Materials Science

ISSN： 0927-7765

eISSN:1873-4367

影響因子：3.902