标題：A dynamic and self-crosslinked polysaccharide hydrogel with autonomous self-healing ability作者：Ding, Fuyuan; Wu, Shuping; Wang, Shishuai; Xiong, Yuan; Li, Yan; Li,Bin; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen

來源出版物：SOFT MATTER 卷：11期：20 頁：3971-3976 DOI: 10.1039/c5sm00587f 出版年：2015

摘要：Natural polymeric hydrogels with self-healing capability that can recover the functionalities and structures of gels after damage are extremely attractive due to their emerging applications in the biomedical field. Here we report a self-healable polymeric hydrogel by self-crosslinking two natural polymers acrylamide-modified chitin (AMC) containing amino groups and oxidized alginate containing dialdehyde groups. The generation of the self-crosslinked hydrogel relies on the dynamic covalent linkage through Schiff base between the polysaccharide chains. The self-healing capability of the crosslinked hydrogel depends on the molar ratio of AMC and oxidized alginate and the surrounding pH. Under certain circumstances, the damaged hydrogel shows a complete recovery and can be stretched to a favorable extent, which is seldom observed for polysaccharide self-healing hydrogel. Notably, we find that the self-healing ability can be "stored" by freeze-drying and "activated" by rehydration. In addition, we demonstrate that the hydrogel can be used as a soft template to guide the repair of inorganic materials like hydroxyapatite. We anticipate that this self-healable hydrogel consisting of biocompatible and biodegradable polysaccharides can be applied to various biomedical fields.

入藏号：WOS:000354449100003

文獻類型：Article

語種：English

擴展關鍵詞：OXIDIZED ALGINATE; POTENTIAL APPLICATIONS; RESPONSIVE CHITIN; SODIUM ALGINATE; DRUG-RELEASE; GELATIN; SCAFFOLDS; CHEMISTRY; OXIDATION; CHITOSAN

通訊作者地址：Shi, Xiaowen; Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

電子郵件地址：shixwwhu@163.com

地址：

[Ding, Fuyuan; Wu, Shuping; Xiong, Yuan; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

[Ding, Fuyuan; Wu, Shuping; Xiong, Yuan; Deng, Hongbing; Du, Yumin; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan

430079, Peoples R China.

[Wang, Shishuai; Li, Yan; Li, Bin] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.

研究方向：Chemistry; Materials Science; Physics; Polymer Science

ISSN：1744-683X

eISSN: 1744-6848