标題：Electrochemical deposition to construct a nature inspired multilayer chitosan/layered double hydroxides hybrid gel for stimuli responsive release of protein作者：Zhao, Pengkun; Liu, Youyu; Xiao, Ling; Deng, Hongbing; Du, Yumin; Shi,Xiaowen

來源出版物：JOURNAL OF MATERIALS CHEMISTRY B 卷：3 期：38頁：7577-7584 DOI：10.1039/c5tb01056j 出版年：2015

摘要：In this study, we report a single electrodeposition process to fabricate multilayered chitosan/layered double hydroxides (LDHs) hybrid hydrogels for stimuli responsive protein release. LDHs nanoplatelets with a regular hexagonal shape were synthesized by a hydrothermal method, and a model protein, insulin, was adsorbed on the surface of the LDHs (INS-LDHs) via electrostatic interactions. The insulin loading ratio could reach 20% (w/w); the INS-LDHs were characterized by energy dispersive spectrometry (EDS), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TG) and zeta potential measurements. Co-electrodeposition of chitosan and INS-LDHs generated an inorganic and organic composite hydrogel with a multilayered structure, as revealed by scanning electron microscopy (SEM). The hybrid hydrogel dramatically reduced the burst release of insulin from INS-LDHs. Notably, the release of insulin was sensitive to the presence of anions, pH, and external potentials. These results suggest that co-electrodeposition of a stimuli-responsive polymer and nanoplatelets is an alternative and facile method to construct hierarchically structured hybrid hydrogels and demonstrate the great potential of the multilayered structure in drug delivery.

入藏号：WOS:000361835300012

文獻類型：Article

語種：English

擴展關鍵詞：LAYERED DOUBLE HYDROXIDE; TARGETED DRUG-DELIVERY; NANOPARTICLES; HYDROGEL; ELECTRODEPOSITION; INTERCALATION; COMPOSITES; ADSORPTION; IBUPROFEN; SYSTEM

通訊作者地址：Shi, Xiaowen;Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

電子郵件地址：shixwwhu@163.com

地址：[Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

研究方向：Materials Science

ISSN：2050-750X

eISSN：2050-7518

影響因子（2014）：4.726