标題：Preliminary study of interactivity between mercury and cells labeled with carboxymethylchitosan coated quantum dots作者：He, Zhenyu; Zhu, Honghao; Zhou, Peijiang

來源出版物：ECOTOXICOLOGY 卷：23 期：10 SI 頁：2030-2034 DOI：10.1007/s10646-014-1357-9 出版年：DEC 2014

摘要：This paper describes the development of a simplified and rapid method for the aqueous synthesis of quantum dots (QDs) with CdTe cores and gradient CdS external shells (CdTe/CdS QDs) aided by microwave irradiation. In order to improve the biocompatibility of the CdTe/CdS QDs, these QDs were then interacted with carboxymethyl chitosan (CMC) so as they could be used as fluorescent probes in the aqueous phase. As fluorescent probes, these modified QDs were successfully used for imaging live Madin-Darby canine kidney (MDCK) cells. Then mercury was incubated with the micro-system formed by quantum dots labeled MDCK. Fluorescence quenching was occurred in the micro-system after 24 h. The micro-system's fluorescence quenching caused by mercury(II) was consistent with the fluorescence quenching equation and displayed a good linearity between the quenched fluorescence intensity of mercury(II). The preliminary results indicated that this micro-system can be used for detection of trace amounts of mercury in vivo and interaction process investigation between mercury and cells.

入藏号：WOS:000345034000025

文獻類型：Article

語種：English

作者關鍵詞：Quantum dots, Carboxymethyl chitosan, Mercury, Cell

通訊作者地址：Zhou, Peijiang; Wuhan Univ, Coll Resource & Environm Sci, Wuhan 430079*, Hubei Province, Peoples R China.

電子郵件地址：hosan9174@gmail.com

地址：

[He, Zhenyu; Zhou, Peijiang] Wuhan Univ, Coll Resource & Environm Sci, Wuhan 430079*, Hubei Province, Peoples R China.

[He, Zhenyu; Zhu, Honghao] Wuhan Ctr Dis Prevent & Control, Wuhan 430022, Hubei Province, Peoples R China.

研究方向：Environmental Sciences & Ecology; Toxicology

ISSN：0963-9292

eISSN:1573-3017