标題: Injectable drug-loaded polysaccharide hybrid hydrogels for hemostasis

作者: Cao, JY (Cao, Jinying); Xiao, L (Xiao, Ling); Shi, XW (Shi, Xiaowen)

來源出版物: RSC ADVANCES  卷: 9  期: 63  頁: 36858-36866  DOI: 10.1039/c9ra07116d  出版年: NOV 11 2019  

摘要: An injectable hydrogel with high adhesion strength, non-toxicity and low cost is highly desired for developing highly efficient hemostasis. In this study, we developed a new type of injectable adhesive drug loaded hydrogel utilizing the formation of Schiff-base linkages based on carboxymethyl chitosan (CMC), gelatin (GEL) and oxidized alginate (OSA). By optimizing the concentration of the biopolymers, the hybrid hydrogel (CMC-GEL/OSA) demonstrated an extremely fast gelation rate (30 s) and adhesive strength of 11 kPa. The freeze-dried hydrogel showed a three-dimensional porous structure. The hydrogel loaded with levofloxacin exhibited good antibacterial properties. Hemostatic performance of the hydrogel was demonstrated in a rat liver injury model. Compared with the untreated wound, the hemostasis time of the hydrogel treated wound was shortened by 84.2% and the blood loss was reduced by 82.2%. Thus, the proposed injectable hydrogel holds great potential applications for hemostasis, drug delivery and in other biomedical fields.

入藏号: WOS:000498519000040

語言: English

文獻類型: Article

地址: [Cao, Jinying; Xiao, Ling; Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Key Lab Biomass Resource Chem & Environm Biotechn, Wuhan 430079, Hubei, Peoples R China.

通訊作者地址: Xiao, L; Shi, XW (通訊作者)，Wuhan Univ, Sch Resource & Environm Sci, Key Lab Biomass Resource Chem & Environm Biotechn, Wuhan 430079, Hubei, Peoples R China.

電子郵件地址: 2013301110176@whu.edu.cn; xiaoling9119@whu.edu.cn; shixwwhu@163.com

影響因子：3.049