标題: Electroassembly of Chitin Nanoparticles to Construct Freestanding Hydrogels and High Porous Aerogels for Wound Healing

作者: Guo, XJ (Guo, Xiaojia); Xu, DD (Xu, Duoduo); Zhao, YN (Zhao, Yanan); Gao, HM (Gao, Huimin); Shi, XW (Shi, Xiaowen); Cai, J (Cai, Jie); Deng, HB (Deng, Hongbing); Chen, Y (Chen, Yun); Du, YM (Du, Yumin)

來源出版物: ACS APPLIED MATERIALS & INTERFACES  卷: 11  期: 38  頁: 34766-34776  DOI: 10.1021/acsami.9b13063  出版年: SEP 25 2019  

摘要: The construction of polymeric nanocomponents into a hierarchical structure poses great importance for subsequent biomedical applications. Herein, we report for the first time the electroassembly of chitin nanoparticles (14 nm +/- 3 nm from transmission electron microscopy) to construct thick and freestanding hydrogels, which can be further dried to obtain high porous and tough aerogels for wound healing. The electroassembly is a simple, straightforward, and controllable process, which crucially depends on the pH of the chitin nanoparticle suspension and the degree of deacetylation of chitin. Interestingly, the electroassembly of chitin nanoparticles is completely reversible, suggesting the physical assembly feature of the freestanding hydrogel. By using supercritical CO2 drying and freeze-drying, chitin aerogels and cryogels can be facilely obtained. Because of the intriguing features (i.e., large surface area, interconnected porous structure, and enhanced hydrophilicity), chitin aerogels demonstrate adorable performance to accelerate the healing of wounds.

入藏号: WOS:000488322900021

PubMed ID: 31429547

語言: English

文獻類型: Article

作者關鍵詞: electroassembly; chitin nanoparticle; hydrogel; aerogel; wound healing

地址: [Guo, Xiaojia; Shi, Xiaowen; Deng, Hongbing; Du, Yumin] Wuhan Univ, Hubei Engn Ctr Nat Polymers Based Med Mat, Sch Resource & Environm Sci, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.

[Xu, Duoduo; Gao, Huimin; Cai, Jie] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.

[Cai, Jie] Wuhan Univ, Res Inst Shenzhen, Shenzhen 518057, Peoples R China.

[Zhao, Yanan; Chen, Yun] Wuhan Univ, Sch Basic Med Sci, Dept Biomed Engn, Wuhan 430071, Hubei, Peoples R China.

[Zhao, Yanan; Chen, Yun] Wuhan Univ, Hubei Prov Key Lab Allergy & Immune Related Dis, Wuhan 430071, Hubei, Peoples R China.

通訊作者地址: Shi, XW (通訊作者)，Wuhan Univ, Hubei Engn Ctr Nat Polymers Based Med Mat, Sch Resource & Environm Sci, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.

Cai, J (通訊作者)，Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China.

Cai, J (通訊作者)，Wuhan Univ, Res Inst Shenzhen, Shenzhen 518057, Peoples R China.

電子郵件地址: shixw@whu.edu.cn; caijie@whu.edu.cn

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